Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

Ashlea Segal; Linden Parkes; Kevin Aquino; Seyed Mostafa Kia; Thomas Wolfers; Barbara Franke; Martine Hoogman; Christian F Beckmann; Lars T Westlye; Ole A Andreassen; Andrew Zalesky; Ben J Harrison; Christopher G Davey; Carles Soriano-Mas; Narcis Cardoner; Jeggan Tiego; Murat Yucel; Leah Braganza; Chao Suo; Michael Berk; Sue Cotton; Mark A Bellgrove; Andre F Marquand; Alex Fornito

Journal article

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F Beckmann, Lars T Westlye, Ole A Andreassen, Andrew Zalesky, Ben J Harrison, Christopher G Davey, Carles Soriano-Mas, Narcis Cardoner, Jeggan Tiego, Murat Yucel, Leah Braganza, Chao Suo, Michael Berk Show all

Nature Neuroscience | Nature Research | Published : 2023

DOI: 10.1038/s41593-023-01404-6

Abstract

The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case–control research, which relies on group mean comparisons. Here we present a comprehensive, multiscale characterization of the heterogeneity of gray matter volume (GMV) differences in 1,294 cases diagnosed with one of six conditions (attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, depression, obsessive–compulsive disorder and schizophrenia) and 1,465 matched controls. Normative models indicated that person-specific deviations from population expectations for regional GMV were highly heterogeneous, affecting the same area in <7% of peop..

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University of Melbourne Researchers

Andrew Zalesky Author

Ben Harrison Author

Chris Davey Author

Michael Berk Author

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Grants

Awarded by Pratt Foundation

Awarded by Viertel Charitable Foundation

Awarded by Schizophrenia Research Institute

Awarded by WU-Minn Consortium

Awarded by McDonnell Center for Systems Neuroscience at Washington University

Awarded by Wellcome Trust

Funding Acknowledgements

[ "This work was supported by the MASSIVE HCP facility (http://www.massive.org.au). We thank B. Fulcher for helpful discussions about this manuscript, S. Oldham and S. Chopra for sharing code to generate the cortical and subcortical brain surface renderings for the figures, and M.L. Seghier for sharing code to generate threshold-weighted overlap maps. This research was supported by the following grants: US Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K99MH127296,. L.P.; 2020 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation, L.P.; German Research Foundation (DFG; project number(s): 513851350 and 390727645), T.W.; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) 016130669, B.F.; grant U54 EB020403 to the ENIGMA Consortium from the BD2K Initiative, a cross-NIH partnership, European College of Neuropsychopharmacology (ECNP) Network ADHD Across the Lifespan'. B.F.; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) 91619115. M.H.; Wellcome Trust (Wellcome) 215698/Z/19/Z, C.F.B.; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) Vici grant no. 17854 and NWO-CAS grant no. 012-200-013. C.F.B.; Norges Forskningsrad (Research Council of Norway) 249795. L.T.W.; Norges Forskningsrad (Research Council of Norway) 298646, L.T.W.; Norges Forskningsrad (Research Council of Norway) 300767, L.T.W.; South-Eastern Norway Regional Health Authority (2018076, 2019101), L.T.W.; European Research Council (BRAINMINT' 802998), L.T.W.; Norges Forskningsrad (Research Council of Norway) 223273. O.A.A.; Norges Forskningsrad (Research Council of Norway) 276082, O.A.A.; Department of Health | NHMRC 1118153. A.Z.; Department of Health | NHMRC 1064643. B.J.H.; Department of Health | NHMRC 1124472, B.J.H.; Department of Health | NHMRC 1024570. C.G.D.; Department of Health | NHMRC 1141738, C.G.D.; Generalitat de Catalunya (Government of Catalonia) SLT006/17/00249, C.S.; Carlos III Heath Institute (PI16/00889 and PI19/01171), C.S.; Secretaria d'Universitats i Recerca del Deparament d'Economia i Coneixement (2021 SGR 01017), C.S.; Secretaria d'Universitats i Recerca del Deparament d'Economia i Coneixement (2021 SGR 00832), N.C.; Carlos III Heath Institute (PI18/00036 and PI21/01756), N.C.; Turner Impact Fellowship from the Turner Institute for Brain and Mental Health. J.T.; Department of Health | NHMRC 1117188. M.Y.; Department of Health | NHMRC 1156072. M.B.; Department of Health | NHMRC 1136344. S.C.; Department of Health | NHMRC 1154378. M.A.B.; Department of Health | NHMRC 1146292, M.A.B.; Department of Health | NHMRC 1045354, M.A.B.; Department of Health | NHMRC 1006573, M.A.B.; European Research Council (ERC, grant MENTALPRECISION' 10100118), A.F.M.; Sylvia and Charles Viertel Charitable Foundation (Viertel Charitable Foundation), A.F.; Department of Health | NHMRC 1197431, A.F.; Department of Health | NHMRC 1146292, A.F.; Department of Health | NHMRC 1050504, A.F. We thank all the sites and investigators who have worked to share their data through data sharing repositories including ABIDE and OpenNeuro. This study was supported by the Australian Schizophrenia Research Bank (ASRB), which is supported by the National Health and Medical Research Council of Australia, the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation and the Schizophrenia Research Institute.", "Additional data were provided (in part) by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. Finally, we would like to thank Nathan Spreng, Michel Thiebaut de Schotten and the anonymous reviewer who provided valuable feedback." ]